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Nodes are connected together via synapses, which are weighted so that the output of one neuron may be attenuated or ampli ed before becoming the input of another neuron Connections among nodes may be arbitrarily complex, but they are often simpli ed through the use of layering Finally, ANNs are trained to solve a particular problem by feeding instances, known as the training set, of the problem in as initial inputs to an ANN, observing the resulting nal output, and then iteratively adjusting the synapses and activation functions until the ANN produces correct outputs for all (or most) of the inputs in the training set Although ANNs can be used for function optimization (see Aarts and Lenstra 1997), they are primarily used directly to generate predictions, as an alternative.

Roses argues that pharmacogenetic tests that predict altered drug handling should not be regulated in the same way as genetic tests that predict risks of disease. Pharmacogenetic tests will not speci cally test the patient for the presence or absence of a disease gene-speci c mutation, nor will they provide any other signi cant disease-speci c predictive information about the patient or family members. . . . The genetics of response to the medicine will be the only data generated using an abbreviated SNP linkage disequilibrium pro le and, practically, could be easily designed, edited and safeguarded to be totally meaningless with respect to any known diseasespeci c mutation. . . . It is therefore incumbent that medical guidelines for Mendelian- or susceptibility-gene testing do not extend automatically to discussion of other types of genetically based pro les in pharmacogenetics (Roses, 2000b). Roses refers speci cally to the Task Force and SACGT recommendations. Given the sparse and not particularly impressive data on the clinical validity and utility of many pharmacogenetic tests, I see no reason why the same standards of validity should not be applied to pharmacogenetic tests as to genetic tests for disease. Moreover, the same possibilities of discrimination based on the results of genetic tests for disease arise for pharmacogenetic tests. First, if a health insurer is asked to cover a pharmacogenetic test for drugs known to be used for certain diseases, the insurer can infer that the patient either has or is at risk of disease. Second, if the result of the pharmacogenetic test reveals that a patient will not bene t from a drug, the insurer or employer may discriminate against the patient, particularly when

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At the producer level, pharmaceutical companies must decide whether targeted drug development is economically feasible Will there be a suf cient return on investment to justify the risks involved in pharmacogenomic research Will companies only pursue research and drug development for diseases for which there is.

. NonThe residual overvoltage protection located at T2 detects the fault at tripping is ensured by time-graded selectivity where the time delays are set such that t H t A + t .

On the last day of our meetings with the factory, Bernie said that he was at the end of his rope. He did not want to change suppliers because of the time it would take to get an alternate up to speed. There was another reason that he had not wished to quit the relationship and it had to do with how King Chemical knew too much about his business. The promise of continued orders had kept the factory from engaging in broader, unscrupulous acts. Once the manufacturing

You can sort data by clicking the gray column headers in the table. Unless you use a lter, you ll often need to scroll after sorting, to sift through extreme values at either end of the spectrum (bounce rates of zero or 100 percent, for example). To sort, open the All Traf c Sources report in your Google Analytics account and sort the rows to nd which referral sources sent you the highest percentage of repeat visitors. You can adjust the number of rows visible in your Data Table from the default 10 rows to a maximum of 500 rows by using the Show Rows pop-up menu at the bottom-right of the table. Expanding the table to 500 rows, however, makes the report load noticeably slower. You can also move a particular row to the top of the table by entering the row number in the Go To text eld, or you can page through all the rows using the arrow buttons in the corner. Using the Go To text eld, paging, or making

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